On 26 April 1986 Reactor 4 at Chernobyl was running a low-power safety test. To run it, operators disabled multiple automatic shutdown systems. The reactor went into an unstable state. The emergency shutdown — when finally triggered — caused, due to a known design flaw, a power surge instead of a power-down. The core exploded.
The principle: A safety test that requires disabling the safety systems is no longer a safety test. The structural irony — protecting against failure by removing the protections against failure — is hard to see from inside a procedure that has a checklist.